Hopes of a breakthrough in the fight against Ebola have
been raised by the 100 per cent successful treatment of monkeys with the deadly
disease.
The experimental drug ZMapp cured the animals even when
administered five days after infection, while they were displaying severe
symptoms.
All 18 rhesus macaques made a complete recovery, in
contrast to three other untreated monkeys that quickly fell seriously ill and
died.
ZMapp is a blend of three laboratory-made antibodies
designed to neutralise the virus.
Two U.S.
doctors given the drug after they were infected with Ebola while working in Liberia
subsequently recovered.
But it is not known whether they were saved by the drug
or just lucky. About 45 per cent of those infected in the current outbreak have
survived without treatment.
At least two other patients treated with ZMapp have died,
possibly because help got to them too late.
The new research, published in a special report on Nature
journal's website, provides hard evidence that the drug works and can be highly
effective.
A team of scientists led by Dr Gary Kobinger, from the
Public Health Agency of Canada, wrote: 'ZMapp exceeds the efficacy of any other
therapeutics described so far, and results warrant further development of this
cocktail for clinical use ...
'We hope that initial safety testing in humans will be
undertaken soon, preferably within the next few months, to enable the
compassionate use of ZMapp as soon as possible.'
The news follows a warning from the World Health
Organisation (WHO) that the Ebola outbreak in West Africa
could eventually claim more than 20,000 victims.
Latest figures show 1,552 deaths from the 3,069 cases
reported so far.
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